I've worked remotely for about a decade now, and have been hiring other remote workers for about half of that time and in my interviews with people, I spend a solid chunk of the time pushing them hard on understanding what it actually means to work remotely - I want them to be damn sure that they are paying attention to their own need for things like contact with other humans, because I've seen enough people burn out on loneliness and quit because they're miserable.
It's more like, cities are not built for everyone to work remotely. If remote was a lot more common, the support structures for it would be more common (some exist, like shared/coworking spaces etc). As remote work expands, cities will adapt to accomodate people working without commuting (which was the norm before industrial times anyway)
The second issue is a personal one, and not exclusive to those that work remotely.