Vastly more different. A place like Houston is going to have “sealed” houses far more frequently than Scottsdale for instance. Sealed meaning the air conditioner will keep the indoor environment manageable. I remember as a kid my grandmother would use that god-forsaken attic fan in lieu of her window-unit air-conditioners and it was pretty much the zenith of misery in a Houston summer.

Natural airflow with the outside at 90% relative humidity isn’t going to do a thing other than make the interior occupants ornery.

The natural airflow design of Apple Park for example, that works incredibly well, but that same design in Houston or New Orleans would be catastrophically ridiculous.