To some extent yes, our choices and scope of action is constrained by our essential nature, some of which is determined before we are even born. However this doesn't absolve us of all accountability. It simply sets up a framework within which we can discuss what accountability is and how we want to manage it.
This is a difficult issue and I don't have all the answers about accountability, I see my take on it as my starting point for the discussion about it not the end. I believe in rehabilitative rather than retributive justice because of this. Also see my reply to fjuerfilis.
I think that morality, love and justice emerge from human nature. I think that I, my self and my consciousness are emergent properties and I'm fine with that. I think that the purpose of human life is chosen for us by the rules of biology, natural selection, game theory and a host of other factors that, seemingly miraculously, lead me to the conclusion that the philosophical Good Life is desirable and largely attainable.