Pre-Existing Immunity to CRISPR Found in 96% of People in Study

Re:Pre-Existing Immunity to CRISPR Found in 96% of People in... by klmr on Wednesday October 31, 2018 @01:05PM (#18347430)

True but that’s purely for legal/ethical reasons, not (directly) scientific ones. Most scientific uses of CRISPR (and other gene editing techniques) by far happen in the germ line. Germ line research (and, thus, applications) are lacking in humans not because it would be scientifically hard, nor because it won’t eventually happen, but because of hard ethical problems with such research.

And the comment that I replied to implies that it is talking about certain applications of genetic engineering which have to happen in the germ line. So I disagree that what it says is “plain wrong”, it’s just incomplete.

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Re:Pre-Existing Immunity to CRISPR Found in 96% of People in... by refurb on Wednesday October 31, 2018 @09:37PM (#18350804)

I’d say it’s less for ethical reasons (though that’s true) and more because the technology for modifying germ lines is nowhere near as advanced as inserting DNA into non-germ line cells.

We have no idea what the impact would be for modifying germ line cells in a developing human being.

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