Drug cocktail almost doubles lifespan of worms

Re:Drug cocktail almost doubles lifespan of worms by onetimemanytime on Monday October 29, 2018 @12:26PM (#18328753)

This makes sense. Glucose at above certain levels ruins cells, so Metformin lowers the glucose level. Asking the doc is key, you can't just read an article and try to find 4-5 meds to take each day :)

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Re:Drug cocktail almost doubles lifespan of worms by cgh on Monday October 29, 2018 @12:40PM (#18328872)

You can also eat a very low-carb diet. Restricting your carbs to foods like greens and berries will have the same effect without the need for a prescription. Gluconeogenesis is demand-driven.

Of course, in the context of anti-aging, Metformin may have other beneficial effects outside of moderating glucose levels.

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Re:Drug cocktail almost doubles lifespan of worms by onetimemanytime on Monday October 29, 2018 @02:50PM (#18330123)

Yeah, but taking a pill and eating what you want (more or less) is much better

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Re:Drug cocktail almost doubles lifespan of worms by village-idiot on Monday October 29, 2018 @12:54PM (#18328983)

Fasting is also a good idea. It forces your body to kill off marginal cells for food, rather than leaving them to potentially become cancer.

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Re:Drug cocktail almost doubles lifespan of worms by _Schizotypy on Monday October 29, 2018 @01:07PM (#18329095)

Can you cite a source please? I would be very interested in reading it

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Re:Drug cocktail almost doubles lifespan of worms by sushid on Monday October 29, 2018 @02:03PM (#18329628)

Not the parent but try searching online for fasting and autophagy. There are countless sources regarding this link.

Another good recent study is the intestinal stem cell regenerative boost after a 24 hour fast in mice.

One might say that the links are still not solid, but we do know that lowering glucose levels might be a good idea (hence the interest in metformin) and fasting/keto certainly achieves that without a drug.

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Re:Drug cocktail almost doubles lifespan of worms by village-idiot on Monday October 29, 2018 @05:50PM (#18331858)

I really like the stuff that Mark Sisson writes on fasting[0], because he explains and links all his sources.

0. https://www.marksdailyapple.com/health-benefits-of-intermitt...

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Re:Drug cocktail almost doubles lifespan of worms by BurningFrog on Monday October 29, 2018 @11:50PM (#18333898)

Oh, that's a cute concrete theory I've never heard before.

I do fast occasionally, but not as often as I'd wish.

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Re:Drug cocktail almost doubles lifespan of worms by village-idiot on Tuesday October 30, 2018 @08:33AM (#18335892)

If you want to learn more, the biological process is called “autophagy”.

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Re:Drug cocktail almost doubles lifespan of worms by JamesBarney on Monday October 29, 2018 @01:38PM (#18329381)

I don't think it's primary effect on lifespan is through glucose regulation. There are other diabetes medications that don't have this same effect.

Also see https://www.gwern.net/Longevity#metformin for more info.

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