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Re:A Blue Pill Is Stopping HIV, World-First Study Shows by killjoywashere on Sunday October 21, 2018 @05:40PM (#18270462)
Interesting problem we're dealing with: Truvada potentially makes it harder to identify HIV+ blood donors (as their antibody titers fall naturally over time) and raises the question of whether HIV+ individuals will be more likely to attempt to donate in order to "prove they're safe". It is a well-known fact in their community that men having sex with men are deferred from being blood donors for 12 months from last male intercourse, and there is at least a vocal minority in the community which feels this is unjust. Presently, there is no approved question for the donor questionnairre along the lines of "Are you using Truvada?" but it is a hotly debated topic among blood bankers.
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by esf on Sunday October 21, 2018 @06:35PM (#18270749)
Truvada does nothing to change identification of HIV+ donors. Truvada does not change response to HIV tests, an HIV+ person taking Truvada as part of treatment does not stop testing positive for HIV antibodies. Nothing changes from the existing blood donation situation due to Truvada.
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by killjoywashere on Sunday October 21, 2018 @06:42PM (#18270786)
Like most things in science, be suspicious of pure logical arguments. The question for any test, even a true-false, is first a matter of "how much". Antibodies fade over time, ergo various vaccine boosters, such as tetanus. At some point, we can't detect it.
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by esf on Sunday October 21, 2018 @07:13PM (#18270930)
It's not a pure logical argument. What you are describing has never been observed though in anyone taking any type of antiretroviral therapy in the now 20+ years of the HAART era. This is a completely unfounded what-if.

The donors you don't want donating are already excluded by existing questions. And if you are that concerned about completely hypothetical unknowns then you might as well also not trust any of the batch testing done on the donors blood anyway. The questions can only ever be a useful prefilter, not a perfect safety net.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by dogma1138 on Sunday October 21, 2018 @07:08PM (#18270901)
I don’t know why is this being downvoted.

Anti bodies are produced to combat a pathogen if the levels of the pathogen are below of what would trigger the immune system you will not produce anti bodies and the ones that you have had produced will fade of over time you don’t have anti bodies for every pathogen you encounter flowing through your blood that would likely kill you.

If the pill can reduce the virus to trace levels and prevent HIV from developing into AIDS it’s not unreasonable to question if it can affect current HIV detection protocols.

Heck it wouldn’t surprise me if they measured the levels of anti bodies dropping while the levels of immune cells remaining normal to test the efficiency of the new drug.

That said I know some HIV tests check for the levels of virions in the blood these are often used for AIDS prognosis I don’t know how sensitive these are and if they’ll be able to detect trace levels of the virus if anti bodies response tests will become unreliable.

Also like with everything it’s not binary if this new treatment regiment can reduce the effectiveness of HIV testing by any meaningful margin it will be a problem.

I have very hard time believing that current HIV testing is 100% false negative proof.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by esf on Sunday October 21, 2018 @07:24PM (#18270965)
The pill was already part of HIV trratment, it does nothing to change the effectiveness of HIV tests.

The only unknown would be whether if you are one of the very, very few people that manages to contract HIV while taking prep, your antibody response is different during that initial window.

But: Anyone in that situation is already covered by the questions about recent partners and already is not donating if answering the existing questions in good faith. If they are donating in this situation at all they are already just ignoring the questions.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by dogma1138 on Monday October 22, 2018 @03:52AM (#18272896)
>The pill was already part of HIV trratment, it does nothing to change the effectiveness of HIV tests.

Where is that stated?

>But: Anyone in that situation is already covered by the questions about recent partners and already is not donating if answering the existing questions in good faith. If they are donating in this situation at all they are already just ignoring the questions.

I think you missed the entire point of the GP this isn’t about someone acting in good faith or rationally.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by chimeracoder on Monday October 22, 2018 @12:40PM (#18276124)
> If the pill can reduce the virus to trace levels and prevent HIV from developing into AIDS it’s not unreasonable to question if it can affect current HIV detection protocols.

It is, because

a) we're talking about PrEP, a treatment for HIV- people

b) Truvada has already been used to treat HIV+ for the past ~15 years.

c) HIV screening for blood donations uses antibody testing, which has nothing to do with viral load.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by Dylan16807 on Sunday October 21, 2018 @08:26PM (#18271222)
> The question for any test, even a true-false, is first a matter of "how much".

So if someone asks "Does strawberry intake affect HIV antibody tests?", the answer isn't "no"?

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by ghkbrew on Sunday October 21, 2018 @08:51PM (#18271331)
Welcome to research and statistics. The most accurate answer is probably something like: "the effect of strawberry intake on HIV antibody testing is not significantly different than zero based on current evidence". There very well may be an effect it's just so small we can't tell it from the noise.
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by sigmar on Sunday October 21, 2018 @08:35PM (#18271255)
>raises the question of whether HIV+ individuals will be more likely to attempt to donate in order to "prove they're safe".

What? This sounds like completely made up scaremongering. Why wouldn't they just get their viral load tested?

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by killjoywashere on Sunday October 21, 2018 @09:33PM (#18271503)
Thinking of remote possibilities and assuming your patients could be lying to you (corollary: trust but verify) is pretty standard practice in medicine.
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by sigmar on Sunday October 21, 2018 @09:51PM (#18271577)
and your solution to these adversarial patients that are willing to lie is to... ask a second question?
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by killjoywashere on Monday October 22, 2018 @03:15AM (#18272766)
Whether Bayesian or Frequentist, surely you can agree the result of different tests are unlikely to have 100% concordance.
Re:A Blue Pill Is Stopping HIV, World-First Study Shows by canekong on Monday October 22, 2018 @03:27AM (#18272810)
As a gay man on prep, I find this comment quite offensive.

Within my circle of friends (some of whom are quite adventurous) none of them says “let’s donate blood and see what happens”.

Furthermore being on PrEP requires strict complete STD testing (Chlamydia, Syphillis, HIV, included) testing every 3 months before allowed to be prescribed again. The same time interval as any recommended STD testing.

I had a discussion with my Dr last week about Truvada on similar topic. Her reply was that Truvada is not enough to suppress viral load and thus they can be detected if a person is infected still and is not on treatment. Also Truvada is not magic pill and can take time to take effect (about 1-2 weeks) and there have been cases of people getting infected while on PrEP because their drugs haven’t taken effect yet.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by flashman on Monday October 22, 2018 @01:05AM (#18272314)
> there is no approved question for the donor questionnairre

Do they not already ask if someone's ever been diagnosed with asthma, hepatitis, HIV, leukemia, lymphoma, myeloma, etc? All of which are permanent disqualifications.

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by dmix on Sunday October 21, 2018 @06:10PM (#18270645)
Is there any centralized ruling for this in the US (and other countries) or is this up to the blood banks.

I'd imagine they'd face liability issues if they were taking blood from high risk individuals. This also applies to intravenous drug users as well (which has nothing to do with sexual orientation).

Re:A Blue Pill Is Stopping HIV, World-First Study Shows by killjoywashere on Sunday October 21, 2018 @06:15PM (#18270660)
Each donor center medical director is responsible for their own checklist, however, The American Association of Blood Banks (AABB) inspects blood donor centers and publishes their questionnairre. Not asking these questions will constitute a hit agaisnt your program and may jeopardize your institution's ability to seek reimbursement for services from, say, CMS.

http://www.aabb.org/tm/questionnaires/Documents/dhq/v2/DHQ%2...