I hold out some hope that the Holographic Universe principle will prove true and tractable, and in the holographic isomorphism there will still be some profound sense in which two entangled photons still somehow locally share a quantum qubit prior to disentanglement.

Don't be fooled by "local" in there; all non-locality results in 4D spacetime would remain true, because of course they have to. It would be "local" in an isomorphism that will be extraordinarily counterintuitive and probably never really be something anyone can "visualize".

But, if this did pan out, there would be a reasonable sense in which the Copenhagen interpretation would have something physics-al about it (as in, grounded in physics, not necessarily "physical" in the traditional sense), where it wasn't in fact "action at a distance". I for one have no problem with the universe creating probability distributions and then randomly picking a result, as some seem to. (The Universe May Do As It Damned Well Pleases. It's true that a good sense of aesthetics has given us a lot of power up to this point, but "I don't think that's very aesthetic" is not a very strong argument. I'll give it more than 0, but not much.)