[1] Where wafers are always in a closed container, no clean room required.
For the closed cell line, which problems are you seeing? Any special use cases for making chips on a process that emphasizes uniquness so much? I mean, apart from maybe being able to do AOI after the front of line processing to hard-route metal around (presumed) defects, in order to reduce the cleanliness requirements for actual monolithic wafers. I mean like if you have a 2D, routing mesh of compute, and you need to worry about routers having defects that tank your yield in wafer-scale chips, you can design the front of line masks to allow wiring one or maybe even more clock delays into the mesh link (without significant cost to the attainable frequency/minimum delay) and also just not connect the link from one or more neighbors over (on the other side of the defect router) to the defect circuity, so that routing between the nodes around the defect one isn't impacted, and neither are any delay cycles. The one node is broken, but it'd just be something a compiler would have to work around.
Other things like hardwired crypto keys might be of use, or hardwired logic for these <15 ppi very, very wide aspect ratio LED screens that are anyway configured for some fixed text to scroll by. Or some analogue IC that is detuned from theoretical values to compensate for the not-precisely-manufacturable discrete capacitors (and inductors), as e.g. the needed Q-factor/voltage of the resonance doesn't allow mechanical trimming components to be used, as they'd induce corona discharge if close enough to not murder the Q-factor.
Digital control is in nowadays even for fast feedback loops, but you can't beat the latency of analogue PD controllers. Good luck compensating single-digit MHz vibration actively with a piezo and e.g. optical interference pattern contrast sensing with some photodiodes like done with 4 of the latter for a CD drive. I'm confident that the power driver is a harder part, given that you want it to follow lumped-element behavior and not distributed-element effects, so you can cope with random noise of sufficiently low frequency to fall within the bandpass range of the control circuity.
I started on the quest because I like to wander around the various auction liquidation shops in the Bay Area which often clean out a building and just sell all the gear they pull out for pennies on the dollar (the recent round of biotech closings lead to lots of refrigerators and incubators and microscopes and such). As I saw 4" and 6" wafer equipment go through these places I asked "What would it take to 'rescue' one of these facilities intact?" (basically a clean room with a full set of machines inside). And made inquiries.
Occasionally I would know someone on the inside who can route my query to the right person but if not one typically ends up at either the corporate development group or the corporate assets group. The sad reality is that the land/space is more valuable than a working, low volume, semiconductor line for 'older' processes.
As a result you have to pay the land use cost rather than the disposal cost and it really isn't an economical sort of thing at all (you'll never be able to make back the money you invest even if you sell the chips). And what that means is that even when you have friends that think it would be 'neat' and could fund such an effort, the math just doesn't pencil out.
If you run at the problem the other way and offer to buy all of the gear, and basically reconstruct the line in a new location, then you have to build a clean room, get a bazillion permits for the chemical storage, build a LNOX plant, and pay to upgrade power to support what the fab needs. Again, the math doesn't pencil out.
What that experience taught me was that in the Bay Area at least, you're not going to be able to purchase/save a fab that the owner no longer wants for any sort of a reasonable price. This is especially true if all you intend to do with it are low volume and open source chips in it.