I personally use Colemak for comfort and it is great to type on. The key presses just seem to flow from beneath my fingertips without effort. My typing speed isn’t very high, but colemak greatly improves the comfort and accuracy of my typing. I also use an ergonomic keyboard because I’m at risk of RSI, though (my day job is programming and one of my hobbies is alright of hand, both are rough on my hands) and being a programmer, my hands are very, very important to me. I’m surprised that so few programmers take care of their hands.