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Re:“Eat More Onions”: Desperate and massively debatable medi... by rb808 on Tuesday September 18, 2018 @01:42PM (#18017443)
Looks likely but not proven. https://en.wikipedia.org/wiki/Syphilis#History

It is interesting. It was terrible that early explorers carried diseases that killed millions in the regions they went to. Its reassuringly symmetric that diseases went the other way as well. I didn't know that 100k+ still die from it every year.

Re:“Eat More Onions”: Desperate and massively debatable medi... by Maultasche on Tuesday September 18, 2018 @07:08PM (#18020099)
Yes, syphilis was first noticed when it started to spread around Europe in the 1490s not long after sustained contact with the Americas. So it's likely that it did come from the Americas, but it hasn't been proven.

It's also possible that it coincidentally originated in Europe around the same time and spread to the Americas. By the time people started looking into where it had come from, it was widespread in both places and the exact origins were obscure. Nobody appears to have recorded the prevalence of syphilis in the Americas during the early years of European contact.