Re:The Omnigenic Model as Metaphor for Life
by westoncb on Friday September 14, 2018 @03:16PM
(#17990046)
I see. That make sense. I had thought we just used it to refer to genome sections related to 'macro traits' (not sure of a better term) we're interested in.
Re:The Omnigenic Model as Metaphor for Life
by dragonwriter on Friday September 14, 2018 @04:49PM
(#17990814)
That is a common use, which shouldn't be surprising because it's how we built a theory around genetics even before we had any idea about DNA. It just turns out in practice that the idea of single distinct unit of heredity, while it works as a close enough approximation for the traits that were observed to establish genetic theory, doesn't work for lots of traits of interest.
It's not; the authors statement seems to use what I udnerstand to be the standard definition used in the field, where a gene is sepcifically a sequence which codes for the synthesis of a particular protein or nucleic acid sequence, which is essentially the lowest level “simple” trait. This is perfectly consistent with large and overlapping sets of genes being involved in determining each of the complex traits that humans mostly care about, and does not make the term “gene” meaningless.