Does mutt talk to the network or have a daemon or run as a service ? I don't know the answer to that but I know that for my own use-case, pine is basically a text editor. It executes no programs or code and does not talk to anything but the local SMTP daemon.
How much sanity checking and bounds checking does sendmail (or postfix or whatever) do on email ? That's the question, I think, because again, in my case, the threat vector is very limited - basically an arbitrary (weird) email or piece of an email that somehow breaks pine.
So no, I don't run it in a container - in fact, I run it as the user whose mail spool is the highest sensitivity asset that user owns ... so a container wouldn't help. If you get the mail spool, you get everything - at least or that user...
I'd probably run it in a non-privileged container.
Infact, I should be doing that for Mutt ...
[1] http://repo.or.cz/alpine.git