IIRC, Noscript had per-domain JS controls before Umatrix existed.

But lacked fine grained control, at least the last time I used it. With uMatrix I can tell the browser to disable something (cookies/script/frames/media etc.) here but keep it enabled else/everywhere and the other way around. It gives the finest possible control but of course requires some time to whitelist the good stuff on new pages. A minor annoyance compared to the control it offers.

I wish it allowed for even finer control, though. What if it could prevent one specific function from running? Or replace tracking functions with no-op ones? Or hook into HTTP APIs in order to let you audit, modify or interrupt communications?

I guess you could use GreaseMonkey for that, though I can't imagine how you could keep track of everything. Might be useful for smallish modifications though.

Yeah, noscript is pretty powerful.

The biggest difference between the two, in my experience, is UX. uMatrix is the best UX for a content blocker I've ever seen - very intuitive and simple.