https://www.reddit.com/r/IAmA/comments/2r3uok/we_developed_a...
https://www.quora.com/Is-AdBlock-legal-If-not-specifically-w...
Their product are the bits they ship to you and the code they run on their servers.
You're modifying a part of their product.
Since you can't modify their product, you also obviously shouldn't be able to use any web browser to view slack because those browsers take those bytes they ship you and interpret them in the context of the browser windowing system (its userChrome.css for example)... that's also clearly modifying the experience they delivered to you.
You also shouldn't be able to use a computer monitor that has color settings different from the web designers working at slack. If you accidentally have a monitor with slightly less blue than theirs, well, you just modified the slack UI to be a little less blue. Obviously a ToS violation and you shouldn't use them at all.
God forbid if you zoom in on the page to modify their product's resolution/size.
Jerk.
Explain.
I was going to comment something similar, but in trying to come up with details and examples to explain my point, I realized I couldn't, I so I decided they aren't really different with respect to modifying a product. What makes them different is how the product was modified, but that presupposes modifying the product and that's not really the way the question has been posed.
Blocking ads is removing the revenue mechanism, and is akin to patching out account verification for a desktop product (assuming the webapp/webpage has some AUP stating that the ads are required to be viewed as part of the service).
Modifying a program takes many forms, from removing authentication mechanisms to fixing bugs or adding enhancements, so while the legal system may or may not acknowledge those differences, it's at best an overly broad description of the case in question.
Blocking ads is not quite the same thing as modifying a product - but I don’t see any obvious reason why an EULA which forbids ad-blocking wouldn’t be enforceable. Though it would be deeply unpopular.