The periods of depression in my life were quite safe and comfortable, and strongly associated with wondering if my life really matters, and you can't think about that too hard because when you do, you recognize that, no, your life is actually pretty trivial in the grand scheme of things.

Hunter Gatherers didn't have that problem, because their whole world revolved around their one little tribe, and at that scale, yes, their actions and choices really did matter.

What a powerful little phrase I’d never heard before. Thanks for sharing this!

The problem is many find a way out of depression via suicide, so that is a very real danger for the chronically depressed.

I cant help but think negotiating those situtations is exaclty what the human needs to avoid depression. Maybe you chances of dying young are much higher, like 30% vs 1%. But die young or die old, those humans really lived.

IIRC, there's is strong reason to discount Maslow's heirarchy as an explanation of anything across different times and cultures, as the number, identity, and order of groups of needs had been shown to not consistently match his and to vary both culturally and, within a culture, in response to changing circumstances.