Note that this study specifically showed that fructose alone did not increase liver fat content unless BPA was present in the solution. See figure 3, but yes, I agree that it would have been nice if they tried BPA without the fructose.

This really does make sense. When that pathway is suppressed, the adipogenic program is activated, which turns on the SREBP-1 pathway and stores lipid droplets. Without this pathway activated, fructose is processed and exported out of the liver, preventing harm to the liver.

I would argue that we should really test every new manmade chemical against a library of our proteins before we synthesize anything new and introduce millions of tons of it to the world. Not doing so can have disasterous consequences.

Samuel Epstein, before he died, documented a great many examples of horror stories we just barely averted. https://www.youtube.com/watch?v=rQoc6WP3QJo