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A comment on Tiny Plastic Is Everywhere. Parent comment

Re:Tiny Plastic Is Everywhere by timr on Monday August 20, 2018 @05:30PM (#17804164)
TCF7L2 is a transcription factor. It is involved in many pathways in human biology, of which diabetes is one.

Observing that it is downregulated in diabetics provides no evidence for or against any theories concerning BPA.

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Re:Tiny Plastic Is Everywhere by subcosmos on Monday August 20, 2018 @05:47PM (#17804304)
It's also the most statistically significant gene, in the whole dang genome, associated with Type 2 Diabetes.

And out of a compound library of 20k chemicals, BPA had the top effect on it.

Seems significant to me

Also worth noting that BPA has been shown to specifically effect the occupancy of TCF7L2 at transcription factor binding sites in Chip-Seq experiments.

http://press.endocrine.org/doi/abs/10.1210/endo-meetings.201...

Lastly, before calling someone else's claims psuedoscientific, you may want to do some homework and check your previous biases. We could certainly use someone with your skills to help model BPAs interaction with the Androgen receptor. Might just save millions of lives....

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