Scientists have successfully transplanted a bioengineered lung into a pig

Re:Scientists have successfully transplanted a bioengineered... by Brakenshire on Sunday August 05, 2018 @07:07AM (#17690731)

I wonder how much this process reverses the age of the lungs, if you take the lungs of an 80 year old, wash them, reseed them and put them in a 20 year old, what’s the result?

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Re:Scientists have successfully transplanted a bioengineered... by biofox on Sunday August 05, 2018 @09:02AM (#17691120)

I don't work in this area, but ECM scaffolds undergo significant change with age. Crosslinks and age-related remodelling degrade the mechanical properties of the scaffold and interfere with normal cell migration and differentiation.

You would want to start with a healthy organ before decellularising and reseeding.

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Re:Scientists have successfully transplanted a bioengineered... by improbable22 on Sunday August 05, 2018 @12:28PM (#17692050)

But perhaps not quite as critical as for current transplants? At least that's my uneducated guess... anyone know?

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Re:Scientists have successfully transplanted a bioengineered... by thefounder on Sunday August 05, 2018 @09:03AM (#17691126)

If that would work I guess people would like to "refresh" their organs anyway from time to time to avoid failure.

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Re:Scientists have successfully transplanted a bioengineered... by dmurray on Sunday August 05, 2018 @07:53PM (#17694228)

Yes, though I would expect the risk of complications from this procedure will outweigh the benefit for healthy patients for many years after it becomes a "routine" operation for those with lung disease.

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Re:Scientists have successfully transplanted a bioengineered... by kls on Monday August 06, 2018 @01:54PM (#17699917)

Weird thought what if a 20'something put cells in a bank and had organs generated from them later in life.

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