If there is already a lively topic ongoing in a room and I need to jump in with another topic, I write a message and say "Hey I have a question, can someone help me?" and then I immediately start a thread with myself so people see that it is a thread and click it to respond rather than just spamming the room.
I have always wanted to try out twistapp and see how it is with their "Thread first" UX mentality.
In my current team that uses Slack, I just made it a policy that all conversations have to be in threads. If they're not I just flip a shit until people give up and make threads again lol. Most people don't care enough to retaliate, so that happened a few times and then everybody got used to the system; this is basically an approximation of Twist now (where the destructive behavior is super easy to commit... sigh)
There's like 3000 people in there. Sometimes shitloads of conversations are happening at once. The people that refuse to use threads aren't cool, they're just co-opting literally the entire channel for just their conversation.
I see it as a forum, where you browse threads and click into the ones you want to discuss in. I guess other people see it as a bloodless Colosseum, may the loudest win.