In this case, the "configuration change" could be a feature flag in the L2 GFEs, something in the L1 GFEs that changed L1->L2 requests in minor ways, or maybe something else entirely (since it's partially security-related: a dynamic LOAS handshake change to use different cyphers? So many possibilities). At the end of the day, though, it's still a specific permutation of all possible features and flags that hadn't been vetted before. Given how large Google's monorepo is, it's not impossible for one of your many dependencies, even indirect ones, which might be configured by another team entirely, to have subtle time bombs that only trigger well after you have built and deployed the code.
Having been on the other side, I know that, for every detail added, a bunch more questions come up.
GFE (Google Front End) is what you connect to when you access any Google services through your browser. Think nginx or even ELB. It's a load balancing reverse proxy, as well as WAF. It's mentioned here https://cloud.google.com/security/infrastructure/design/ and probably in the SRE book. This report might be the first time Google mentions in public that there can be two levels of GFEs, but I remember at least one service using such a setup many, many years ago.
« These features had been introduced into the second layer GFE code base but not yet put into service. One of the features contained a bug which would cause the GFE to restart; this bug had not been detected in either of testing and initial rollout. »
...but yeah, they definitely could have done better.