Yes. They are designed for that stuff. Here's the biggest accident (in France) from having a large object on the tracks: 80 ton oversized load. Only the engine car derailled.

    Trainset involved: 70 (Sud-Est) 
    Service: train 736, Grenoble to Paris 
    Location: PN 74, Voiron
    Injuries: 2 dead, 60 injured
    [Edit: date: 23 September 1988]

    A special road transport with a weight of 80 tons became stranded on level
    crossing 74. Train 736, rounding a curve toward the crossing, ploughed into it
    at 110 km/h (68 mph). The large mass of the road vehicle made this crash much
    worse than it might otherwise have been; the engineer and one passenger died,
    and many more were injured when the first trailer was ripped open by debris.
    Only the leading power unit derailed. This wreck, the most violent to date,
    became a reference for the design and crash testing of safety features for the
    next generation of TGV, as embodied by today's Duplex trainsets. These newer
    trains have several deformable sections, at the front and rear of the power unit
    and at the front of the first trailer, to manage and absorb crash energy without
    damage to passenger compartments. Trainset 70 was never returned to service, and
    the trailing unit 23140 became a spare in the Sud-Est fleet.