Dying Organs Restored to Life in Novel Experiments

Re:Dying Organs Restored to Life in Novel Experiments by tambourine_man on Monday July 16, 2018 @08:07AM (#17540622)

But where do we get those new mitochondria from? I'm almost afraid to ask.

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by tahoe1780 on Monday July 23, 2018 @11:32AM (#17593408)

http://www.lifeextension.com/magazine/2010/ss/rejuvenate-you...

http://www.lifeextension.com/Magazine/2010/2/Reverse-Mitocho...

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by nine_k on Monday July 16, 2018 @08:51AM (#17540877)

Maybe from cloning one's own cells, then carefully dismantling them to free up mitochondria without damaging them? I don't think a lot of the tissue should be required (that is, ounces, not pounds).

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by logfromblammo on Monday July 16, 2018 @11:13AM (#17541900)

If adipose cells could be used for this purpose, a small amount of liposuctioned fat would be adequate.

And if pounds are needed, well... let's just say there should be plenty of eager donors for those who don't have enough.

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by aldoushuxley001 on Monday July 16, 2018 @09:35AM (#17541138)

mitachondria are living organelles, they could simply be induced to replicate until the desired quantity is reached.

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by tomjen3 on Monday July 16, 2018 @10:57AM (#17541757)

If I recall bio from school, they are super adapted to living in animal cells -- they probably couldn't survive on their own.

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by aldoushuxley001 on Monday July 16, 2018 @11:46AM (#17542220)

It's true that they very much rely on a nuclear genome, because some of their genes required for independent replciation have been lost. But surely there's a framework that enables the mass replication of mitochondria using our own cells as a source material.

I doubt blood would work because red blood cells contain effectively very minimal, if not zero, mitochondria (depending on stage of cycle).

Funny enough, the best bet might be taking mitochondria from sperm or egg. Human sperm have ~50-75 mitochondria per cell. There's on average 50 million sperm cells per ml of ejaculant and the average is 2.5ml per ejaculation, so 125 million mitochondria could potentially be harvested from an average guy in a single go, provided the extraction is an unrealistic 100% efficiency.

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by bjelkeman-again on Monday July 16, 2018 @12:50PM (#17542747)

50 million/ml x 2.5 ml x 50 = 6.25 billion, is what I get the number to be.

[ Parent | on HN ]

Re:Dying Organs Restored to Life in Novel Experiments by aldoushuxley001 on Monday July 16, 2018 @04:25PM (#17544775)

Ah yes, I totally botched the math. Thanks for that.

So 6.25 billion potentially harvestable mitochondria per average sperm donation.

Hard to say how much might be needed for a rejuvination test, but those seem like viable numbers.

[ Parent | on HN ]