~50 million people live within 300 miles of Cleveland vs about ~16 million within 300 miles of SF.
All of these are about 400 miles away, some less than 300.
And did you edit your comment, because I think it originally said 500 miles.
I grew up in Akron, the former Rubber Capital of the World. There is literally nothing in Northeast Ohio but cornfields, soybeans, brutal winters, and rusting artifacts of the 20th century economy. Columbus could be a good choice for growing tech firms to add a second HQ due to OSU being a pretty decent school, but Cleveland really has nothing going for it. The geographical advantages that led to it's existence and growth during the industrial revolution have gone and will never return.
You are still speaking a bit too strongly though. There is plenty of things in NEO. For starts world class museums and cultural institutions (having been rich in the past helps).I'm living in San Francisco right now, but I could definitely see myself going back someday
http://aqicn.org/map/northamerica/
And compare to:
Do you know what else is within 300 miles of Cleveland Ohio?
Absolutely nothing.