I took a dose of acid so large that I had to curl up under my bed sheet for the two hours of the peak.

Once the peak left and I could again walk around and brave the sunlight, I realized I was ravenously hungry. I grabbed a grapefruit and began devouring it.

More than halfway through the fruit's succulent sectors, I felt overwhelmed again as if the peak had returned and had to seek darkness for another twenty minutes.

Most drug interactions are hard to detect. Do I notice if the amphetamine is hitting 15% harder or weaker than usual? Or if I'm focusing 15% better or worse? Not really. Feels arbitrary to try and measure it.

But re-crossing acid's threshold immediately after exiting it was the hard evidence I needed to believe in what always sounded like highschool folktale.

Also garlic extract, curcumin and piperine (or bioperine), change how things are metabolized and processed in the liver. I take those and they amplify the effect of a medication I take, so I have to be extra careful with dosage.

On the flip side you can often get by with lower dosages, which in some cases mean less side effects.

I concur. The medication was in fact causing nasty side effects and I was able to cut the dosage in half. I may even be able to ween myself off it entirely once I find the right combination of natural alternatives.