I've worked from home for about eight months now, from my bedroom, with my wife two kids (ages four and two) at home. I've always scored about 50-50 on any test that measures introversion vs. extroversion. I will be the center of attention in social situations, but I don't really seek them out, so work was really the only way I made friends before. So I see my social circle (as it was) dwindling as I work longer from home.

I think the weirdest thing I've noticed is a decline in verbal communication skills. It's much harder to express myself verbally, much easier in writing. My company has only recently started doing video rather than voice-only calls, which has helped. I also try to get people to video chat any time I help them with something instead of trying to handle it over slack.