When a man's salary depends on him doing his job poorly, is it really all that surprising that he will cut corners?

If you don't reward (By issuing grants for) negative results, or null results, or replicating prior studies, why do you expect that scientists will aim for any of those outcomes?

It seems to me since we don’t yet know the truth around large swaths of reality (dark matter and such topics), a replication crisis is exactly what we should expect

You have to eliminate a lot of possibilities in a universe with this much detail

The real issue, again IMO, is more of an “expectation crisis”. We expected to repeat this and failed to. Because we’re still a ridiculously ignorant species lacking conscious awareness of many aspects of reality