Re:Michael Pollan reluctantly embraces the 'new science' of ...
by tpm on Thursday May 17, 2018 @09:26AM
(#17091070)
Apparently not that horrible, with 25mg of psilocybin:
Treatment with psilocybin produced rapid and sustained antidepressant effects. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks.
https://www.nature.com/articles/s41598-017-13282-7
The conditions are almost a sure fire way to make someone have a troubling experience if they were given the doses knowen to be taken in those times and did not have prior experience dealing with the reality altering effects of those substances.