When I was at University of Waterloo in the 80s, I went for a couple of talk therapy sessions with a very nice, empathetic woman employed in the Psych department. After a session, she said, "would you like to see something?"

Just adjacent to her office was a "trip room", probably constructed when the building was build in the 70s (?). It was round, completely lined with acid orange fabric, upholstered like a pasha's tent and filled with cushions in every colour imaginable. No doubt it had a superlative quadraphonic sound system installed. It also had a large, smoked glass window, for "observers." Not ideal for mushrooms perhaps but for other things...

It wouldn't be science but at the same time those conditions are horrible in order to study the effects of psychedelics.

The conditions are almost a sure fire way to make someone have a troubling experience if they were given the doses knowen to be taken in those times and did not have prior experience dealing with the reality altering effects of those substances.

Apparently not that horrible, with 25mg of psilocybin: Treatment with psilocybin produced rapid and sustained antidepressant effects. Decreased depressive symptoms were observed in all 19 patients at 1-week post-treatment and 47% met criteria for response at 5 weeks. https://www.nature.com/articles/s41598-017-13282-7