Might be obvious, but the biggest thing you'll give up in this market compared to cities like Toronto or Montréal is selection. There's some larger companies with satellite offices here (IBM, Salesforce, etc), but not too many startups.

One word of caution about real estate in the Fredericton area; don't buy any property too close to the river. There's usually flooding in the spring from the snow melt up stream and this year was especially bad. I was lucky enough not to be affected, but there's lots of homes taking flood damage right now.