I saw an example a while back of an SO question about "how should I store gender (sex) in a database". Conflating the two may alienate or upset a transgender individual, without the participants in the Q&A ever being aware of that person. Maybe they're a new user with no ability to comment to point it out, and they just head elsewhere from then on.

Similarly, if minority groups are more prone to imposter syndrome, it may be that aggressive and blunt answers impact them disproportionately.

In both of these cases, it needn't be intentional or directed at any particular individual to have a disproportionate impact on a group of people. Just as a group can get a reputation of being a "boys club" without explicit "no girls" rules.