Dangerous in the context of which career would you choose, a plumber at $50k where work is intermittent and you can get hurt and be out on your ass, or study for accounting or programming or any other office position where you have pretty much zero risk, but you'll probably making even more money and at a stable employer.

Sitting at a desk in an office all day is a recipe for a heart attack. Every job has it's dangers and tradeoffs.

I don't think that's comparable since that can be mitigated with proper diet and exercise, and also using sit stand desks.