Re:Tracking the Illegal Shipment of Sarin Precursor from Bel...
by pcrh on Thursday April 26, 2018 @02:02AM
(#16929191)
"The dose makes the poison". It would be too broad to claim that all serine hydrolyases are susceptible to all organophosphate compounds.
For example many pesticides are organophosphates, yet have little effect on humans.
The only reason the wholesale disruption of hydrolases is not the thing that kills you with nerve agents is that acetylcholinesterase is particularly susceptible to organophosphates (wide open active site) and essential to nerve signal conduction. Thus although sarin (for example) will wreck most hydrolases in your body, this won't really matter when you'll be dead in a few minutes from your nervous system being unable to tell your lungs to breathe.
[0] https://en.wikipedia.org/wiki/IDFP
[1] https://en.wikipedia.org/wiki/Methoxy_arachidonyl_fluorophos...