The tip, the only part which touches the paper, is made of iridium[1], or similar, which is very hard. As far as I can tell that doesn't wear. Some very old or specialise/custom nibs may use softer metals and perhaps wear would be a possibility on those but in any instance I can't see you wanting a flat spot to develop.
[1] It turns out that modern iridium nibs probably aren't made of iridium. I was looking into wear on them and found, amongst others, this https://www.nibs.com/blog/nibster-writes/wheres-iridium which does into detail analysing the composition of a fair number of nibs. Down the rabbit hole!
Not every nib is flexible. My Duofold and Meisterstück certainly aren't, my cheap Noodler's Ahab just to a limited extent (but it is a special steel flex nib).