I started feeling a slight discomfort in my wrists a few months in to my first job. My manager suggested that I expense a new keyboard, recommending the kinesis advantage.

It took me a good 2 weeks to become proficient on it, but that was four and a half years ago and I haven't felt any RSI symptoms at all. I think I'm now faster on it than my old keyboards, mostly due to the thumb clusters. I recommend it to everyone who asks about it.