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Re:WxPython 4.0.0 Released by amelius on Thursday February 01, 2018 @12:54PM (#16283977)
My biggest problem with wxpython is that you apparently can't set closures as event handlers. Instead, you have to define a member function, and register it. This makes the process a bit tedious compared to JavaScript.
Re:WxPython 4.0.0 Released by ptx on Thursday February 01, 2018 @03:17PM (#16285463)
The documentation seems to claim[1] otherwise:

  It also allows the direct binding of events to:

    * A handler method in the same or another object.
    * An ordinary function like a static method or a global function.
    * An arbitrary callable object.
If it works for arbitrary callable objects it should certainly work for closures.

[1] https://docs.wxpython.org/events_overview.html