Not useless in general, just useless for me
I once wrote a Python program to compile GUIs[1] -- you input a description of the GUI as a text file and it outputs Python code that implements the GUI in Tkinter. I dusted this off for a project last year but eventually decided that making it web-based would be easier to write, look nicer, and have more functionality.
Obviously if other people find WxPython useful, good luck to them.
But probably shouldn't because we don't produce enough renewable energy yet. There's still something to be said about using TRUE native apps.
I'd write a web app and expose it on 127.0.0.1:someport rather than electron (which is bloated). Going down IgorPartola's list:
Text editor - I'd probably make this terminal-based using curses. Then I could easily use it on a remote server I'm ssh'd into.
video, audio editor - I've no plans/desires to write anything like these
system widgets and settings - a web app is highly suitable for editing system settings
web browser - far too big a project for me!
terminal emulator - plenty of good ones around already. I mostly use KDE's konsole.
git GUI client - I've recently been adding some git functionality to my catwiki wiki software (a web app) https://github.com/cabalamat/catwiki
crypto coin wallet - web app
chat client - web app or terminal-based
games - I've considered writing a hex-based board wargame as a web app
document editor - my catwiki wiki software is this, I suppose
security focused software a la Keybase client - the last time I wrote security software was a zero-user-interface email encryption system. If I did something like that in future, any interface would be web based
It's unlikely that cabalamat would attempt making most of those and the others could definitely be done as a web/electron app if desired.