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Re:Microsoft disables Spectre mitigations as Intel’s patches... by evmar on Monday January 29, 2018 @11:30AM (#16258420)
For Chrome we had to go through a lot of extra effort to make updates not break us.

http://neugierig.org/software/chromium/notes/2011/08/zygote....

Re:Microsoft disables Spectre mitigations as Intel’s patches... by kuschku on Monday January 29, 2018 @12:16PM (#16258873)
Or you could explicitly design the package so that your pre/postinstall scripts ensure that you install to a separate directory, and rename-replace the old directory, so you can’t get half-finished updates.

Regarding the rest, if your code has incompatible API breaks between two patch or minor version changes, you’ll need to rethink your development model.