I'm sure conservatives would put up w/cannabis in exchange for effectively overturning Roe vs Wade, which is the effect this would have precedentally.

It was all the "liberals" and the phony "originalist" Scalia who ruled for the government in Gonzales.

https://en.wikipedia.org/wiki/Gonzales_v._Raich

That is all B.S. though. The real issue is federal vs. state power and that has nothing to do with left and right.

Only 20% of Americans polled are against abortion entirely, it's not the powerful topic it used to be. You're right that marijuana prohibition is not a strongly supported topic either, or at least one that is met with a growing indifference. Almost no one (outside of Sessions) seems to have held strong opinions on the matter.

But regardless I highly, highly doubt this one law being overturned could be equated to states having free reign to do whatever they like, regardless of federal law. There are tons of these individual issues that are finely regulated between state and federal power balances.

Not to mention the Supreme Court doesn't work like politics where you trade one issue for going easy on another.

Roe isn't based on the commerce clause, so overturning Raich's Commerce Clause application wouldn't be particularly relevant to it.

OTOH, dodging the Commerce Clause and adopting a broad 10th Amendment interpretation might affect Roe, but a 10th Amendment interpretation powerful enough to affect otherwise Constitutional federal legislation (which Roe is not) would have broad and severe effects on federal power generally, far beyond marijuana policy and Roe.

We forget that America cares very little for democracy, being largely an oligarchy.