I've had the same experience, I've just taken to whitelisting all of the cache, assembly, and lib folders throughout the workflow (and processes).

Never found an AV which didn't seriously hamper build times, since building often involves a lot of process start/stops and new small files, both of which are kryptonite to AV.

MalwareBytes Enterprise recently got completely uninstalled as it was locking random files during compilation indefinitely. They have a fix but only for the consumer branch.