Has anyone got any experience using Emacs with one of those mail tools and gmail with 2FA? I started playing with notmuch half-heartedly but it seemed to expect a local mail store, which is fine but I found myself bouncing between setup instructions for several different tools and I quickly gave up.

I would like to get it working; Apple Mail client is a bit slow on my laptop with a high volume, and I'm all about plaintext and keyboards. I'd happily use Emacs.