I ran Pi-Hole for a few weeks, and found it was more trouble than it it was worth. Because it blocks at the DNS level using (very large) DNS blacklists. It was cumbersome to temporarily whitelist domains when you hit a site that just wouldn't load properly as you had no idea which of the many domains that site was requesting were being blocked. By comparison, using an in-browser adblocker you can just disable the the adblocker and reload the page, and once done, a single click re-enables the adblocker again. Also, Pi-Hole used to be undetectable by anti-adblocker scripts, but now it isn't.

Although very good at what it does (almost too good in fact) it is a blunt instrument that may or may not suit your needs.