So have I, and I've had extreme reactions to both. LSD was actually the easiest on me if I consider my worst experiences together. A bad mushroom trip, being the worst of the worst, left my personality in tatters and it took me over a year to truly recover from the experience. Marijuana induces crippling anxiety in me. I was having issues sleeping a few years ago, so I got a medical card. Even one hit was overwhelming. When I was a late teenager, I would smoke a couple times a week and it was generally fine. I'm not sure how or why my body responds the way it does but, personally, it's not at all fun and not at all relaxing or mind expanding in the ways most people suggest. It's just a really shitty time and it's mostly impossible to talk to other users about it because they don't have these responses and don't understand it.

A bad trip will happen if you take a psychedelic when you are not in a particularly good mood.

If something has been recently bothering you, or you are stressed or depressed or angry about something, those feelings are going to come up to the surface and manifest in very unpredictable ways, given the nature of hallucinogenics.

I learned that lesson myself. Never take a psychedelic unless you are in a good place, emotionally.

It's a moot point for me, at this point in my life. Hopefully it's good advice for someone else. With the psychedelics, we're talking about a 2-3 year period of my life that started roughly 20 years ago. And what you're saying is all common knowledge to myself and my then-friend group. I honestly have no idea what my frame of mind was but I don't recall ever starting a trip in a bad state of mind. I just know that I had good trips and I know that I had bad trips. And the bad trips went very, very bad and grew over time in both frequency and intensity. Maybe I was taking too much? It didn't seem like it, at the time, at least in retrospect. Who knows.

But then, I can't reconcile these things with my experiences with medical marijuana in 2012, either. I was a recreational smoker for probably 4 or 5 years of my life before the bad mushroom trip (after which, I wholesale quit drugs the very next day and also didn't have a drop of alcohol for 5-6 years). I never really experienced much anxiety from marijuana in my youth, but when I went back in 2012 it was a totally different ball game. I worked with my dispensary to try to sort out a strain that would help me and came up short.

FWIW, I opted instead to address the utter lack of physical activity in my life and it sorted out the sleep issues and has persisted to today.