There are rough edges. Upgrades, recovery from corrupted hot backup, etc. But it's very easy to rebuild the cluster in flight, for example when changing some fundamental cluster property, or after a PEBKAC, (with a not too big read-only window), though it requires plus one node, a regular MySQL/MariaDB server that acts as a donor (where Galera can bootstrap from), but that's not too surprising if you want to at least serve read-only requests.
If you really want no-ops deployment, use something that requires minimal amount of ops, like ElasticSearch. Just give it an obscene amount of RAM and it'll work fine for ages.
RDS or not, if you want to run a big site, you'll need (dev)ops expertise. And a lot of it. Famously, Netflix - the big full-cloud business, - employs the most aggressive performance engineering and other "auxiliary" development groups. (Because AWS is fckn!1 expensive, and when you can run on a thousand less nodes, it'll cost you less. And yes, of course Netflix gets a big discount, but you won't, at least not initially.)
HFT, adtech, scientific engineering and many other industries are magnitudes farther ahead.
This is the worst joke in tech really. Developers/Managers all jumping on the "cloud" bandwagon because "hey we don't need ops" and then you end up with "Galera is such a POS, you can't use it with RDS".. <facepalm>
I can assure you this is not the case if your indexes are very large and their number is constantly growing, and/or clients are doing very complex queries that stress the system.
And you have to plan ahead and start with a large number of shards, to be able to scale your ES cluster.
Yet it's much better than trying to get some kind of SQL based cluster going, because those require knowledge of a lot of subtle internal details.
Restoring a backup takes minutes for multi-TB restores.
Also consider if the backups are compressed -- a 1TB compressed file also takes time to uncompress. If the data compresses well, you could even run into the disk being the bottleneck, not the network.
[0] Well, more than that; those numbers assume you're actually getting the link rate with no overhead, which of course isn't reality.
1TiB=1,000GiB; if your drives do 300MB/sec, that's still one hour.
That's not multi-master. That's single master with a hot standby.
> any hiccups in replication can be dealt with using restore.
Restore isn't an option when your database is so large that it takes most of a day to copy the backup onto the replacement master to restore from it. (Not speaking hypothetically here.) Obviously restoring from a backup is still there as a last resort in this case, but you really don't want to have to go there.