"model vs reality" implies a very clear delineation between theory and data. Bayesian models muddle that up - particularly with (based on my understanding of) the standard model. (Insert the classic statistical decision theory debate about classic/Bayesian models here.)

What I really wonder about is how, if ever, we will refine our abilities to observe the finer grains - and to what extent that's possible. I remember physicists discussing the observations possible given particle accelerator size from lectures in undergrad. The future was not very bright.