> i.e. psychologically or physically dependent on the drug to the point of ruin or death

That's not what dependence means. That could be an outcome. And each of those drugs has a different potential outcome from long term use.

Take for example the difference between marijuana and cigarettes. Cigarettes are much more addictive, and have clear evidence of causing lung cancer. It would seem logical that marijuana would also cause lung cancer, but there is not enough evidence to say for certain that it does.

So dependence on cigarettes can definitively kill you. Dependence on marijuana might make you less employable, but it's not certain that it might kill you.

It would seem logical that smoking marijuana would also cause lung cancer. But there are many other ways in which you can take it.

Why would it seem logical that smoking marijuana would cause lung cancer? That seems like an overly simplified model for cancer.

Anyway, there is no data showing smoking marijuana causes lung cancer (rather, there is no high quality data. I'm sure some NIDA-funding scientists have found otherwise, but it's not considered correct).

The NSF review concluded that, at most, smoking marijuana causes respiratory problems, but not lung cancer. The only type of cancer positively associated with marijuana smoking was a form of prostate cancer, which happens to be easily treated.

Logical in a sense that it's a reasonable initial premise in the absence of other evidence. Not saying that it's true, but if you don't know if it's true or not, and you know that smoking other things does give you cancer, that's the side I'd err on.

nope, the null hypothesis is "smoking something does not give you cancer". That smoking other things gives you cancer is specific to what they contain.

Yeah, those are not numbers that would indicate "rare" for any other medical condition.

I think they are if you multiply through by the number of people who'd want to try them (legal or illegal) in the first place.

The thing is War on Drugs is doing more harm than good.