The biggest issue with the Windows Store is the forced installation of several apps that do not belong in an enterprise environment, unnecessarily increasing attack surface.
I'm not going to get into the details of sandboxing here, but needless to say managed applications running in a sandbox are a big improvement over unmanaged, unsigned applications running with admin rights.
Sadly even now I run into large software companies that require users to have local admin privileges(and disable UAC) for their software to function correctly. And that's in the finance sector.
I've been dealing mostly in the healthcare sector now and it's even worse. Particularly with imaging software vendors. I deal with some that still only support Windows XP.
A famous example from the car industry is McLaren having a stack of 25-year-old Compaq LTE 5280 laptops, running DOS, because that's the only machine that will run the proprietary CA card module for the diagnostic software for the McLaren F1 (106 cars produced '92-'98, 100 left today, each valued north of $10 million).
Try removing CandyCrushSaga and Facebook, and XBoxIdentityProvider(among many others)...they come right back after the next round of updates.
If you're going allow Windows Store with all of its junk(that you have very little control over), might as well allow Bonzai Buddy, Ask Toolbar, and Super PC Cleaner 2017 Premium Edition Recommended Microsoft!
And the argument that Windows Store apps are more secure so even if a ad or application is malicious the damage is limited doesn't hold water. A quick google will bring up tons of examples of code escaping sandboxes, even entire virtual machines. Any environment, no matter how secure, will always benefit from a reduction in attack surface area.