"local' anticancer treatment is achievable but not really effective. the promise in the CAR-T is persistence of the cells and systemic distribution so they can surveil for micro metastases and minimal residual disease, hopefully eliminating it. I'm not sure injecting a ton of cell into ones taint would give the cells the best opportunity to persist and provide systemic prevention.

What I got out of the article was that the approach here seems to be that you create a small number of improved t-cells and inject them. Then these improved t-cells will respond correctly upon contact with cancer cells. At that point they will multiply to meet the required demand. The initial injection would be more like a vaccine than a drug.

The t-cells would multiply? I thought they were created in the bone marrow. Do bloodstream t-cells go through meiosis?

i second that question. if they can carry out needle biopsies of the prostate and other cancer locations, if they can surgically remove cancerous tissue -- why can't they also get these modified cells to the cancerous locations somehow?