I spent the last 32 years coming up with interesting problems to solve. Even though most of them never went anywhere, it's obvious to me that there is a bigger perspective where everything I've learned fits in. Ironically; my best advice I can give is to follow your passion; solve the problems you care deeply about, the best way you can think of, and don't bother so much with other peoples opinions. Unless you're in it for awesome profits, in which case I'm probably the worst person to answer.