Vanilla KSP makes you do everything by hand. That's part of the fun, IMO, but after you get good at landing and docking it can turn into a chore when you need to fly multiple missions to e.g. build a colony. However, there are many mods that will let you automate some or all parts of the gameplay.

Two particular mods worth mentioning are MechJeb, the autopilot for everything, and kOS, which lets you code up your own guidance system.