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Re:A working, transistor-scale replica of the MOS 6502 micro... by userbinator on Sunday May 21, 2017 @10:50AM (#14387550)
Someone did try using SPICE to simulate the 6502, and it was much slower than the real hardware:

http://forum.6502.org/viewtopic.php?t=1768

it took about 30 mins to run through reset and then 20mins to do 10 cycles of instructions.

Re:A working, transistor-scale replica of the MOS 6502 micro... by dom0 on Sunday May 21, 2017 @03:26PM (#14388762)
That's to be expected. Transient SPICE analyses can become really slow for larger circuits (couple real-ps/CPU-s for analog circuits that work with a few dozen MHz).